Global Oncology Academy

The Hypoxic Tumour Microenvironment: From Basics to Therapeutics

The Hypoxic Tumour Microenvironment: From Basics to Therapeutics
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    The management of metastatic cancers has changed significantly over the last decade with improved understanding of its underlying pathophysiology a...
    • Overview

      The management of metastatic cancers has changed significantly over the last decade with improved understanding of its underlying pathophysiology and signal pathways. However, a significant proportion of patients with metastatic colorectal cancer or metastatic squamous cell carcinoma of the head and neck has a poor prognosis, in many cases due to late presentation. For those patients, cure is typically not possible; treatment options can prolong life and improve symptoms.  Thus, long-term survival rates in these metastatic settings, while improving, remain unacceptably low.

      Despite advances, the management of patients with metastatic disease continues to present challenges for clinicians. As innovative focused therapeutic options become available and treatment paradigms evolve, the need to discern when and how to incorporate these promising agents into clinicians’ armamentarium presents a great educational need. Moreover, continuing advances in our understanding of cancer pathophysiology, molecular pathways, the optimal and sequential use of targeted therapies in the context of chemotherapy and radiotherapy in the metastatic setting and the therapeutic potential of investigational agents currently being explored for various cancers, suggest educational and clinical practice gaps that must be effectively addressed to further improve outcomes in patients with cancer.

      Given this information, Siyemi Learning in partnership with Prova Education, presents this module titled “The Hypoxic Tumour Microenvironment: From Basics to Therapeutics”. This module provides the foundational knowledge necessary for clinicians to better understand the role and physiologic effects and consequences of hypoxia in the tumour microenvironment, the mechanism of action of hypoxia-inducible factors, and how these collectively influence malignant progression in several cancers while providing the basis for targeted therapeutics. 

    • Learning Objectives

      At the completion of this module, participants will be better able to:

      1. Describe the role and physiologic effects and consequences of hypoxia in the tumour microenvironment
      2. Describe the processes associated with malignant progression in the hypoxic tumour microenvironment
      3. Identify genes and/or molecular pathways influenced by hypoxia
      4. Explain the role of hypoxia in resistance to therapy in patients with cancer
      5. Assess the clinical value of investigational agents targeting hypoxia in the tumour microenvironment
    • Commercial Support

      This activity is supported by an independent educational grant from Merck KGaA, Darmstadt, Germany.
       
      Original Release Date: 
      5 February 2015
      Expiration Date: 5 February 2017

    • Disclosure of Conflicts of Interest

      COURSE DIRECTOR

      Jan B. Vermorken, MD, PhD
      Emeritus Professor of Oncology
      Department of Medical Oncology 
      Antwerp University Hospital 
      Edegem, Belgium
      Financial Relationship Disclosure
      Consultant: Amgen, Genentech, Merck Serono, Shionogi      
      Commercial Interest Speakers Bureau: Merck Serono

      REVIEWER

      Wafik S. El-Deiry, MD, PhD, FACP
      Rose Dunlap Professor and Chief, Hematology/Oncology
      Associate Director for Translational Research, Cancer Institute
      Penn State Hershey Medical Center
      Hershey, PA - USA 
      Financial Relationship Disclosure
      Receipt of Intellectual Property Rights: Morphotek, Oncoceutics, Inc.         
      Ownership Interest: Oncoceutics, Inc., p53-Therapeutics, Inc.

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